Viruses like SARS-CoV-2 may have been circulating in bats for decades
Research has concluded that the lineage from which SARS-CoV-2 came has been circulating among bats for decades. The researchers found that the virus which causes Covid-19 diverged from other bat viruses about 40-70 years ago. They warn SARS-CoV-2 is likely to include other viruses with the ability to infect humans. The lineage that gave rise to the SARS-CoV-2, the virus that is responsible for the Covid-19 pandemic, has been circulating in bats for decades, researchers report. They also warn it likely includes other viruses with the ability to infect humans. The discoveries, which researchers made by reconstructing the evolutionary history of SARS-CoV-2, have implications for the prevention of future pandemics stemming from this lineage. “Coronaviruses have genetic material that is highly recombinant, meaning different regions of the virus’s genome can be derived from multiple sources,” says Maciej Boni, associate professor of biology at Penn State. “This has made it difficult to reconstruct SARS-CoV-2’s origins. You have to identify all the regions that have been recombining and trace their histories.” A SARS-CoV-2 ‘family tree’ The team used three different bioinformatic approaches to identify and remove the recombinant regions within the SARS-CoV-2 genome. Next, they reconstructed phylogenetic histories for the non-recombinant regions and compared them to each other to see which specific viruses have been involved in recombination events in the past. They were able to reconstruct the evolutionary relationships between SARS-CoV-2 and its closest known bat and pangolin viruses. The researchers found that the lineage of viruses to which SARS-CoV-2 belongs diverged from other bat viruses about 40-70 years ago. Importantly, although SARS-CoV-2 is genetically similar (about 96%) to the RaTG13 coronavirus, which was sampled from a Rhinolophus affinis horseshoe bat in 2013 in Yunnan province, China, the team found that it diverged from RaTG13 a relatively long time ago, in […]